Children with CHIT1 variants, high mold exposure at increased risk of exacerbations
Publish date: Jun 25, 2010
FRIDAY, June 25 (HealthDay News) – High mold exposure in the home may lead to an increased risk of severe asthma attacks among children with variants in the chitinase gene CHIT1, according to research published online June 10 in the American Journal of Respiratory and Critical Care Medicine.
Ann Chen Wu, M.D., of the Harvard Pilgrim Health Care Institute and Harvard Medical School in Boston, and colleagues analyzed data from 395 white children, aged 5 to 12 years, who underwent genotyping of 48 single nucleotide polymorphisms (SNPs) in two chitinases — CHIT1 and CHIA — and the chitinase 3-like 1 gene, CHI3L1, and a CHIT1 duplication. Their household mold levels were assessed from house dust samples.
The researchers found that the combination of high environmental mold exposure and CHIT1 variants was associated with an increased risk if severe asthma attacks involving emergency department visits and hospitalizations in a four-year period.
“Both in vitro and in vivo studies have demonstrated that chitin and chitin derivatives have important immunologic effects and play an important role in pulmonary inflammation. The literature suggesting the importance of chitinases in the pathophysiology of asthma is strong, and chitinases may play a role in future targets for asthma therapy. In future genetic studies of asthma, measurements of fungal levels could contribute important knowledge on the pathophysiology of asthma,” the authors write.
Thank You National Apartment Association. I will do my best to get this very important information out ASAP to numerous owners, investors, huge property management companies (e.g., Riverstone Residential), attorneys, and judges, AND, of course, to the MANY people who are currently living in MOLD-INFESTED APARTMENT COMPLEXES right now! katy
Political Action Committee – National Apartment Association (NAA) files Amicus Brief in mold case (two infant deaths in mold filled apt – Wasatch Prop Mgmt) citing US Chamber/ACOEM ‘litigation defense report’ to disclaim health effects of indoor mold & limit financial risk for industry
“Changes in construction methods have caused US buildings to become perfect petri dishes for mold and bacteria to flourish when water is added. Instead of warning the public and teaching physicians that the buildings were causing illness; in 2003 the US Chamber of Commerce Institute for Legal Reform, a think-tank, and a workers comp physician trade organization mass marketed an unscientific nonsequitor to the courts to disclaim the adverse health effects to stave off liability for financial stakeholders of moldy buildings. Although publicly exposed many times over the years, the deceit lingers in US courts to this very day.” Sharon Noonan Kramer
Information about Riverstone Residential, the Louisiana Housing Finance Agency, and the owners of Jefferson Lakes Apartments in Baton Rouge, Louisiana allowing tenants to be exposed to extreme amounts of toxins from molds by intentionally concealing evidence
Irrefutable evidence indicates that Riverstone Residential, Guarantee Service Team of Professionals, & plaintiffs’ attorney, J Arthur Smith III, must have agreed to exclude evidence that would have shown the owners of Jefferson Lakes Apartments & Riverstone Residential had knowledge of the severe MOLD INFESTATION at the complex before we moved in